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Table 3 Salient Grade 3 or Worse Adverse Events Attributed to Neoadjuvant Study Treatment

From: Results of a planned interim toxicity analysis with trimodality therapy, including carboplatin AUC = 4, paclitaxel, 5-fluorouracil, amifostine, and radiation for locally advanced esophageal cancer: preliminary analyses and treatment recommendations from the North Central Cancer Treatment Group

ADVERSE EVENT

ABSOLUTE INCIDENCE

NUMBER OF PATIENTS WITH EVENT

death (paclitaxel reaction)

1

1

neutropenia

11

9

leukopenia

12

10

febrile neutropenia

5

5

hypotension

4

3

vomiting

4

3

nausea

2

2

dehydration

2

2

diarrhea

2

2

dysphagia

6

6

electrolyte abnormalities

6

4

dyspnea

1

1

pain (non-specific)

1

1

rash

1

1

mucositis

1

1

fatigue

2

2

syncope

1

1

hypersensitivity

1

1

neuropathy

1

1

infection

1

1

melena

1

1