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Table 4

From: Lymphoscintigraphy and triangulated body marking for morbidity reduction during sentinel node biopsy in breast cancer

Suggested optimized lymphoscintigraphy technique
Camera/Outlining:
- High resolution low energy cast (non-foil) collimator [38,96,97].
- 128 × 128 matrix-dynamic, 256 × 256 matrix-static.
- Upwardly offset 99mTc energy windows and separate 57Co energy windows (122 kev) [38,43,77,96].
- Decayed 57Co sheet source transmission outlining to limit exposure [38,96].
Injection:
- Anesthetic cream (EMLA) applied to injection sites for 30+ minutes [38,43,77].
- Hybrid radiotracer injection technique: Concurrent perilesional (2–4 ml biased away from the axilla) and areolar-cutaneous "junction" injections "LymphoBoost " (LB), (0.2–1.0 ml). Total dose: 150–400+ uCi 99mTc sulfur colloid for same day injections and surgery, 500–1000+ uCi for next day surgery. Higher LB volumes towards 1.0 ml tend to visualize nodes quicker and brighter but delineate more echelon nodes compared to lower volumes of 0.2 ml [38,40,43,72,74].
- High specific activity preparation, 100% filtered [130].
- Lidocain added to sulfur colloid syringe for additional pain control [38,43,77].
- Mild/short massage only [131].
- Deeper sub-lesional injections for internal mammary SN visualization if deemed important [113].
- Contamination control [77].
Acquisition sequences:
- Optional post perilesional injection views.
- Dynamic lateral 100 frame 10 second images during areolar-cutaneous "junction" injection "LymphoBoost" (LB) [38,43,72,74].
- Optional immediate post dynamic early static sitting/standing views (see below).
- Delayed supine anterior and oblique 45° views with the arm out in the 90° surgical position and lateral views with the arm up towards the head with triangulated body marking of anterior and oblique 45° views.
- 57Co sheet source transmission outlining of anterior and lateral views [38,43,96].
- Sitting/Standing views highly recommended (see below).
Additional optional maneuvers:
- Perform perilesional injection followed by 30 minute (or more) delayed views followed by LB injection (dynamic see above). Alternately delete perilesional injections altogether (only inject LB).
- Adaptive Injection Technique (AIT), re-inject different volumes of radiotracer based on imaging results [40],(data pending publication).
- Tape breast displacement for small breasts, for large/pendulous breasts use sitting views (see below) [38,43,96].
- Prone imaging [112], MOVA position [127], next day follow up views if two day.
- Avoid lead shielding the injection site [42,96,97].
Triangulated body marking:
- See figure 2, [38,40,43].
Sitting/Standing views:
- Highly recommended end of study anterior and lateral sitting/standing views with arm out in the 90° surgical position with chest pressed up against collimator (best resolution), two 1 minute frames each position to address motion if it occurs [38,40,43,67-71,96]. Works best in large breasted women.
Display:
- Adjustment of upper level, gamma curve, pre-display low level data enhancement (pre-scale/contrast/threshold) and appropriate image summation [96].
- Viewing dynamic sequences in cine mode [107].
Printing:
- Two sets of images for final supine views (marking views): with and without 57Co transmission scan (when performed) [38,96].
- Print images large enough for surgeons to clearly see anatomy. Optionally print sitting views and/or dynamic sequences if important [38,96,107].
Reporting:
- Timely and detailed communications with surgeon before surgery to discuss findings, meaning/convention of markings and complex patterns. Number of SN based on supine and standing views, appearance sequence and perceived intensity, 3-D position in body, any extra-axillary or intramammary nodes, dilations/ectasias.