Does the timing of breast cancer surgery in pre-menopausal women affect clinical outcome? : an update

Table 1 Summary of key studies

Year	Author	Study Design	Outcome measure	Outcome difference	P value
2003	Takeda [31]	Retrospective n = 36	Disease-free survival	Nil	n/a
2002	Fentiman [29]	Prospective n = 249	10 year survival	84% luteal 54% follicular	-
2001	Pujol [30]	Prospective n = 360	Disease-free survival	nil	n/a
1999	Nomura [32]	Retrospective n = 721	Disease-free survival	nil	n/a
1998	Mangia [33]	Retrospective N = 248	Disease-free survival	Nil	n/a
1998	Harlap [34]	N = 614	10-year survival	nil	n/a
1997	Goldhirsch [35]	RCT n = 300	Disease-free survival (ER-ve)	59% luteal 42% follicular	P = 0.008
1997	Vanek [36]	Retrospective	Overall Survival	Nil	n/a
1997	Mondini [37]	N = 165	Overall Survival	Nil	n/a
1995	Jager [38]	Retrospective n = ?	Disease-free survival	nil	n/a
1995	Holli [39]	N = 267	Overall Survival	nil	n/a
1994	Kroman [40]	N = 1635	Overall Survival	nil	n/a
1994	Corder [41]	N = 157	Overall Survival	nil	n/a
1994	Saad [42]	Retrospective N = 96	Overall Survival	79% lut 40% foll,	P < 0.001
1992	Gnant [43]	Retrospective n = 385	Overall Survival	nil	n/a
1991	Badwe [27]	Retrospective n = 75	Overall survival	54% follicular 84% luteal	P < 0.001
1991	Senie [44]	Prospective n = 283	Disease-free survival	71% luteal 57% follicular	P = 0.02
1989	Hrushesky [7]	Retrospective N = 44	Overall Survival	95% luteal 79% follicular	-