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Table 1 Summary of key studies

From: Does the timing of breast cancer surgery in pre-menopausal women affect clinical outcome? : an update

Year Author Study Design Outcome measure Outcome difference P value
2003 Takeda [31] Retrospective
n = 36
Disease-free survival Nil n/a
2002 Fentiman [29] Prospective
n = 249
10 year survival 84% luteal
54% follicular
-
2001 Pujol [30] Prospective
n = 360
Disease-free survival nil n/a
1999 Nomura [32] Retrospective
n = 721
Disease-free survival nil n/a
1998 Mangia [33] Retrospective
N = 248
Disease-free survival Nil n/a
1998 Harlap [34] N = 614 10-year survival nil n/a
1997 Goldhirsch [35] RCT
n = 300
Disease-free survival (ER-ve) 59% luteal
42% follicular
P = 0.008
1997 Vanek [36] Retrospective Overall Survival Nil n/a
1997 Mondini [37] N = 165 Overall Survival Nil n/a
1995 Jager [38] Retrospective
n = ?
Disease-free survival nil n/a
1995 Holli [39] N = 267 Overall Survival nil n/a
1994 Kroman [40] N = 1635 Overall Survival nil n/a
1994 Corder [41] N = 157 Overall Survival nil n/a
1994 Saad [42] Retrospective
N = 96
Overall Survival 79% lut
40% foll,
P < 0.001
1992 Gnant [43] Retrospective
n = 385
Overall Survival nil n/a
1991 Badwe [27] Retrospective
n = 75
Overall survival 54% follicular
84% luteal
P < 0.001
1991 Senie [44] Prospective
n = 283
Disease-free survival 71% luteal
57% follicular
P = 0.02
1989 Hrushesky [7] Retrospective
N = 44
Overall Survival 95% luteal
79% follicular
-