From: Venous gangrene and cancer: A cool look at a burning issue
• Supra-therapeutic level of INR ≥ 6.0 |
• *Acquired Protein C and protein S deficiency as result of warfarin treatment |
• *Heparin induced thrombocytopenia, after initiating or continuing warfarin therapy |
• *Cancers of the pancreas, lung, stomach and adenocarcinoma of unknown primary. |
• *Positive anticardiolipin antibodies |
• *Obesity and metabolic syndrome |
• Cancer treatment (chemotherapy or hormonal e.g. tamoxifen) |
• Surgical operations |