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Table 1 Expression levels of the GEFs studied related to NPI status of the tumours

From: The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer

 

Guanine Nucleotide Exchange Factors

NPI status

TRIO

VAV1

TIAM-1

(NPI < 3.4)

109 ± 44

0.45 ± 0.22

1957 ± 1466

(NPI 3.4–5.4)

234 ± 113

1.18 ± 1.06

506 ± 205

(NPI > 5.4)

315 ± 176

0.45 ± 0.41

298 ± 123

  1. NPI = Nottingham Prognostic Index.
  2. Levels of Trio showed a sequential increase with increased NPI status with a significant increase from NPI1 to NPI2 (p = 0.04). Expression of Vav1 showed no definitive pattern while TIAM-1 expression showed a sequential decrease with an increase in NPI status.
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International Seminars in Surgical Oncology

ISSN: 1477-7800