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Table 1 Expression levels of the GEFs studied related to NPI status of the tumours

From: The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer

  Guanine Nucleotide Exchange Factors
NPI status TRIO VAV1 TIAM-1
(NPI < 3.4) 109 ± 44 0.45 ± 0.22 1957 ± 1466
(NPI 3.4–5.4) 234 ± 113 1.18 ± 1.06 506 ± 205
(NPI > 5.4) 315 ± 176 0.45 ± 0.41 298 ± 123
  1. NPI = Nottingham Prognostic Index.
  2. Levels of Trio showed a sequential increase with increased NPI status with a significant increase from NPI1 to NPI2 (p = 0.04). Expression of Vav1 showed no definitive pattern while TIAM-1 expression showed a sequential decrease with an increase in NPI status.