The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer

Table 3 Expression levels of the three GEFs studied related to clinical outcome

	Guanine Nucleotide Exchange Factors
Survival status	TRIO	VAV1	TIAM-1
1 Disease free	174.1 ± 62.1	0.89 ± 0.48	60.3
2 Metastatic disease	263 ± 151	0.01 ± 0.003	169
3 Local recurrance	152.4 ± 94.5	0.02 ± 0.012	26
4 Died from breast cancer	188.6 ± 97.2	0.03 ± 0.016	225

Trio levels show little change of expression between patients who survived and patients who died from breast cancer. Vav1expression was highest in patients who remained disease free while TIAM-1 expression was much lower in patients who remained disease free compared with those who died from breast cancer.