Uterine PEComa: appraisal of a controversial and increasingly reported mesenchymal neoplasm

Fadare, Oluwole

doi:10.1186/1477-7800-5-7

International Seminars in Surgical Oncology

Table 1 Clinical features of the 44 reported cases of uterine PEComa***

From: Uterine PEComa: appraisal of a controversial and increasingly reported mesenchymal neoplasm

REFERENCE	Year	Age (yrs)	TSC	Location	Management	Outcome
Hornick & Fletcher (39)	2008	34	NS	Corpus	NS	NERM at 33 months
Armah & Parwani (40)	2008	59	No	Corpus	Hysterectomy/BSO performed 7-years previously for presumed leiomyosarcoma; Renal and pulmonary metastases at current presentation; all resected	NERM at 15 months
Liang et al (41)	2008	59	Yes	Corpus	Hysterectomy/BSO/Pelvic and paraaortic Lymphadenenctomy, omentectomy, appendectomy, peritoneal biopsies; hormonal therapy	Extension into cervix at presentation; NERM at 10 months
Gan et al (20)	2007	40	NS	Corpus	Hysterectomy	NERM at 16 months
		33	NS	Corpus	Hysterectomy	NERM at 32 months
		44	NS	Corpus	Hysterectomy	NERM at 52 months
Rammeh Rommani et al (21)	2006	35	No	Corpus	Excision	NERM at 4 months
Azad et al (22)	2006	25	No	Cervix	Radical hysterectomy, Lymphadenectomy	Unavailable or Recent
Folpe et al (13)	2005	59	No	Corpus	Adjuvant Chemotherapy	Liver and Lung metastases at 30 months. Alive with metastases 30 months
		56	No	Corpus	Adjuvant Chemotherapy and radiotherapy	Lung and bone metastases at 11 months; Alive with metastases 11 months
		36	No	Corpus	Hysterectomy, adjuvant chemotherapy	Lung metastases at 12 months, liver metastases 36 months; Death at 39 months
		42	No	Corpus	No additional surgery or adjuvant therapy	NERM at 11 months
		28	No	Cervix	Hysterectomy and Lymphadenectomy	NERM at 36 months
		48	No	Cervix	Adjuvant Radiotherapy	NERM at 21 months
Jeon et al (23)	2005	9	No	Corpus	Neoadjuvant chemotherapy, Hysterectomy with Lymphadenectomy, Adjuvant Chemotherapy/Radiotherapy	Lymph node metastases at presentation, NERM at 18 months
Bernado Vega et al (27)	2005	34	No	Corpus	Hysterectomy/BSO	Unavailable or Recent
Bosincu et al (24)	2005	59	No	Corpus	Hysterectomy/BSO, omentectomy, abdominal exploration	Pelvic recurrence at 6 months; Death at 12 months
		48	No	Corpus	GnRH analogues, then Hysterectomy	NERM at 36 months
Fukunaga (25)	2005	40	No	Corpus	Hysterectomy/BSO, omentectomy, Adjuvant chemotherapy and radiation.	Ovarian and Omental metastases at presentation, Death at 16 months
		30	No	Corpus	Hysterectomy	NERM at 36 months
		36	No	Corpus	Hysterectomy	NERM at 6 months
Fukunaga (25,26)	2004	32	No	Corpus	Excision	NERM at 12 months
Gao et al (28)	2004	60	No	Corpus	Hysterectomy/BSO, staging	Unavailable or Recent
Darai et al (29)	2004	18	No	Corpus	Excision	Pelvic recurrence and lymph node metastases, 6 months, NERM subsequent 24 months
Fadare et al (5)	2004	41	Yes	Cervix	Hysterectomy/BSO	NERM at 35 months
Dimmler et al (32)	2003	61	NS	Corpus	Hysterectomy	Lung metastases at 84 months
Greene et al (30)	2003	79	NS	Corpus	Hysterectomy/BSO	Pelvic and abdominal recurrence at 24 months; Death at 24+ months
Park et al (31)	2003	32	No	Corpus	Hysterectomy/RSO	Right broad ligament/mesovarian extension at presentation; NERM at 18 months
Vang & Kempson (33)	2002	40	No	Corpus	Excision	Unavailable or Recent
		54	No	Corpus	Hysterectomy/BSO	Unavailable or Recent
		56	No	Corpus	Hysterectomy/BSO	Unavailable or Recent
		75	No	Corpus	Hysterectomy/BSO, Adjuvant Radiotherapy	NERM at 31.2 months
		47	No	Corpus	Hysterectomy/BSO	NERM at 1.5 months
		49	Yes	Corpus	Hysterectomy/BSO	NERM at 54 months
		55	No	Corpus	Hysterectomy/BSO	NERM at 2 months
		58	No	Corpus	Hysterectomy/BSO	Unavailable or Recent
Bonnetti et al (34)	2001	19	No	Corpus	Hysterectomy/BSO/pelvic and inguinal lymphadenectomy, Adjuvant chemotherapy and radiotherapy	Metastases to pelvic/inguinal nodes and vaginal extension at presentation. Local recurrence, bone and lung metastases 18 months; no further follow-up
		41	Yes	Corpus	Hysterectomy/BSO	Ovarian metastases at presentation, NERM at 6 months
Michal & Zamecnik* (35)	2000	58	No	Corpus	Hysterectomy	NERM at 48 months
		48	No	Corpus	Hysterectomy	NERM at 48 months
		46	No	Corpus	Hysterectomy	NERM at 12 months
		46	No	Corpus	Hysterectomy	NERM at 12 months
Ruco et al** (38)	1998	56	No	Corpus	NS	Ovary and ileum metastases at presentation
Pea et al (19)	1996	57	No	Corpus	NS	NERM at 24 months

TSC tuberous sclerosis complex; BSO bilateral salpingo-oophorectomy; NERM no evidence of tumor recurrence or metastases. *these authors [35] published a subsequent opinion in which they indicated that their cases are better designated epithelioid smooth muscle neoplasia [36].
**Presumes the same case is being described in references 37 and 38. ***Includes cases published in the English literature before 01/31/08 only, and excludes the case reported in reference 53 due to lack of data.

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