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Table 1 The IHC scoring system of HER2

From: The role of Herceptin in early breast cancer

Staining pattern Staining score
Membrane staining is observed in < 10% of the tumour cells 0
A partial and faint membrane staining is detected in > 10% of the tumour cells 1+
A weak to moderate complete membrane staining is detected in > 10% of the tumour cells 2+
A moderate to strong complete membrane staining is detected in > 10% of the tumour cells 3+
  1. Those tumours which score 0 or 1+ are regarded as negative, those scoring 2+ are borderline and 3+ are positive.