Synthesis of 2,6-trans-disubstituted 5,6-dihydropyrans from (Z)-1,5-syn-endiols

Certain (Z)-1,5-syn-diols 2 may be converted into 2,6-trans-5,6-dihydropyrans by using phosphonium salt 4 or phosphorane 5 as dehydrating agents. A more general four step procedure converts the (Z)-1,5-syn-endiols into enantiomeric dihydropyrans ent-3 via regioselective silylation of the allylic alcohol unit followed by mesylate formation and base-promoted nucleophilic displacement.


Findings
We recently reported a one-pot double allylboration reaction sequence which provides (Z)-1,5-syn-endiols from simple aldehyde starting materials with excellent diastereo-and enantioselectivity. [1] In connection with an ongoing natural product synthesis project, we were interested in developing methods to transform diols 2 into dihydropyrans 3 or the enantiomeric dihydropyrans ent-3 through complementary, regioselective cyclodehydration processes (Scheme 1).

Scheme 1
The challenge of synthesizing dihydropyrans 3 or ent-3 from 1,5-diols such as 2 lies in the differentiation of the two hydroxyl groups. Selective activation of the allylic alcohol in 2 as a leaving group followed by nucleophilic attack by the homoallylic alcohol will lead to dihydropyran 3. However, activation of the homoallylic alcohol followed by nucleophilic attack by the allylic alcohol will This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.   1 2, 91-95% ee provide the enantiomeric dihydropyan ent-3. Cyclic ethers of various ring size have been synthesized by the cyclodehydration of diols through the use of oxyphosphonium salts and phosphorane reagents. [18][19][20][21][22][23] We reasoned that because the rate determining step of these cyclizations is believed to be the nucleophilic substitution step, selective formation of 3 should be possible owing to the superior leaving group ability of the activated allylic hydroxyl. [21] Diol 2a (R 1 = R 2 = CH 2 CH 2 Ph) was used initially in the development of a suitable cyclodehydration protocol (Figure 1). Because the R 1 and R 2 substituents of 2a are identical, steric effects on the activation of the two hydroxyl groups are eliminated. Therefore, the enantioselectivity of the ring closing step will depend only on the relative rates of the competing cyclization processes leading to 3a and ent-3a. Initial attempts at cyclization of 2a using Ph 3 P and diethyl azodicarboxylate or Ph 3 P-CCl 4 were low yielding (entries 1, 2). [22] Interestingly, small amounts of the 2,6cis-disubstituted dihydropyran 6a were detected under these conditions, suggesting the intervention of a competitive double inversion process or a carbocation-mediated cyclization process. In order to avoid the presence of nucleophilic counter ions, we turned to the use of phosphonium salt 4 and phosphorane 5 as the cyclodehydration reagents (Scheme 2). [24,25]

Scheme 2
Treatment of diol 2a with 4 in acetonitrile (0.05 M) at 0°C and warming slowly to 23°C provided a 9 : 1 mixture of trans and cis dihydropyrans 3a and 6a in 65% combined yield (entry 3). We speculated that the cis isomer might arise via formation of an allylic cation (perhaps facilitated by acid formed by competitive elimination of the oxyphosphonium salt during the reaction). Accordingly, the trans/cis ratio was improved to 13 : 1 by addition of 2,6tert-butyl-4-methyl-pyridine as an acid scavenger (entry 4). Ultimately, we found that use of CH 2 Cl 2 as the solvent and Et 3 N as base provided 3a in 78% yield with 20:1 trans/cis selectivity (entry 5). However, chiral HPLC analysis indicated that 3a from entry 5 had an enantiomeric excess of only 25% e.e. while the enantiomeric purity of the starting diol 2a was 91% e.e.
This result suggests that the selectivity for displacement of the two hydroxyl groups of 2a is only ca. 2 : 1 under these conditions. Examination of molecular models indicates that in order for the activated allylic alcohol to be displaced in this intramolecular substitution process, the allylic C-O bond substantially deviates from coplanarity with the adjacent π-system. Therefore, the difference in relative rates of displacement of the two activated hydroxyl groups is much less than originally anticipated. The enantioselectivity could be increased to 90% by lowering the reaction temperature to -78°C, but the yield of dihydropyran 3a was reduced to less than 50% (entry 7).
Dehydration of 2a with phosphorane 5 in toluene at 80°C in the presence of triethylamine provided exclusively trans dihydropyran 3a in a yield of 71% and 50% e.e. (Figure 1, entry 9). Attempts to increase the enantioselectivity of the reaction by lowering the reaction tempera- Cyclodehydration of diol 2a   Table) O P h Ph 6a + ture were thwarted by the poor solubility profile of 5. Changing the solvent from toluene to hexanes, THF, or NMP also did not significantly impact the %e.e.
Given that the cyclodehydration reactions of diol substrates were complicated by selectivity and reactivity issues (Figures 1 and 2), we turned to an alternative strategy which would not rely on chemoselectivity in the cyclodehydration step. To this end, mesylates 11 were synthesized (Scheme 3).

Scheme 3
Treatment of 1,5-diols 2 with TBS-Cl and imidazole effects selective protection of the allylic alcohol (Scheme 4). The mono-TBS protected 9 is the major product in all cases except when 2f was used as the substrate; in this case, the allylic hydroxyl is more hindered than the homoallylic hydroxyl, which is silylated preferentially. The homoallylic TBS ethers 12 and the bis-TBS ethers 13 can be conveniently recycled. The origin of the regioselectivity of the selective silylation of 1,5-diols 2 is unknown at present. Subsequent treatment of mono-TBS ethers 9 with methanesulfonyl chloride (MsCl) followed by deprotection of the TBS ether by using 3HFEt 3 N afforded mesylates 11 (80 -≥ 95% yield). Treatment of mesylate 11a with 1 equivalent of potassium tert-butoxide in tert-BuOH (0.01 M) between 40-50 °C provided ent-3a in 75% yield and 10:1 selectivity for the dihydropyran product and a diene resulting from an undesired E2 elimination (Figure 3, entry 1). [26,27] This result was particularly gratifying since Thomas has reported that attempts to cyclized suitably activated 1,5-diol substrates under basic conditions did not afford dihydropyran products. [28] It was necessary to carry out the reactions under dilute conditions in order to minimize elimination to diene 14. However, increased steric demands about the mesylate (11b) or the allylic alcohol (11c) led to increased amounts of elimination, although the isolated yields of the dihydropyrans 3b and 3c were acceptable (Figure 3). Treatment of mesylate 11e containing cyclohexyl groups flanking both the allylic alcohol and the mesylate gave a 1:1 mixture of ent-3e and 14e. α-Oxygenated substrates 11d and 11f cyclized with 3.5:1 and 3:1 selectivity under these conditions.

Scheme 4
It is known that tributylstannyl ethers are decent nucleophiles and are considerably less basic than oxanions. [29,30] Indeed, we found that elimination products 14 could be suppressed by treatment of alcohols 11 with (Bu 3 Sn) 2 O in benzene followed by heating the resulting tributylstannyl ethers in DMF at 80°C (Figure 3). In this way, selectivity for the formation of dihydropyran ent-3 versus elimination could be increased up to 99:1 for substrates 11a, 11d, and 11f. All other substrates examined also showed improved selectivity for pyran formation, and in all cases the dihydropyran ent-3 was obtained in at least 72% yield.
In summary, the scope of cyclodehydration reactions of (Z)-1,5-syn-diols 2 to give the the targeted dihydropyrans 3 using 4 and 5 as dehydrating reagents in a one-pot procedure is limited to substrates that lack oxygen substituents at positions adjacent to the leaving group. Acceptable enantioselectivity can be achieved by performing these cyclodehydration reactions at low temperatures. However, a much more general procedure for synthesis of the enantiomeric dihydropyrans ent-3 involves the stannyl ether mediated cyclization of hydroxy mesylates 11. This method relies on a selective silylation of the homoallylic alcohol, and represents a new route to access 2,6-trans-disubstituted 5,6-dihydropyrans. Application of this methodology in natural products synthesis will be reported in due course.

Supporting Information Available
Experimental procedures and full spectroscopic data for all new compounds (42 pages).