- Case report
- Open Access
Cutaneous metastasis to the face from colon adenocarcinoma. Case report
- Georgios Fyrmpas†1Email author,
- Nikolaos Barbetakis†2,
- Andreas Efstathiou†2,
- Iordanis Konstantinidis†3 and
- Christodoulos Tsilikas†2
© Fyrmpas et al; licensee BioMed Central Ltd. 2006
- Received: 07 November 2005
- Accepted: 02 February 2006
- Published: 02 February 2006
Facial skin metastases from colorectal cancer are extremely rare and appear several years after resection of the primary tumour. They are an important finding, often being the first sign of metastasis from a previously treated colon cancer.
We describe a case of a 69 year old patient with cutaneous metastasis to the chin from a previously treated adenocarcinoma of the colon. The patient presented with dyspnoea, pleuritic pain and loss of weight. A chest x-ray revealed a right upper lobe mass of the lung which on subsequent surgical exploration proved to be metastatic from colorectal adenocarcinoma resected three years ago. During the postoperative course, a nodule was noted on the chin and excision biopsy revealed it was also a metastasis from the initial colorectal cancer. Palliative chemoradiotherapy was administered and the patient survived 8 months.
High index of suspicion is necessary for the early detection of facial cutaneous metastases from colorectal cancer. The aim is to start treatment as soon as possible before widespread visceral metastases occur. Cutaneous metastases from colorectal cancer carry a better prognosis in comparison to those of other epithelial tumours.
- Colorectal Cancer
- Colon Adenocarcinoma
- Excision Biopsy
- Facial Skin
- Cutaneous Metastasis
Cutaneous metastases in the facial region occur in less than 0.5% of patients with metastatic cancer and they usually originate from malignant melanoma . Colon adenocarcinoma metastasises to the facial skin very rarely and only 4 cases have been reported in the English language literature to date [1–3]. In this report we describe an unusual case of colorectal cancer metastasising to the chin and lung.
Lung and breast cancers are the commonest epithelial malignancies metastasising to the skin in men and women respectively . Clinically, cutaneous metastases manifest as nodules, ulceration, cellulitis like lesions, bullae or fibrotic processes. Histologically, they are classified as adenocarcinoma, squamous cell carcinoma, undifferentiated carcinoma and other miscellaneous types .
Colon adenocarcinoma most often metastasises to the liver and lung. Cutaneous metastases occur in less than 4% of all cases . The most frequent site is the abdominal skin and specifically the area of previous surgical incisions . Direct spread from the initial tumour or dissemination via lymphatics account for this type of metastasis. If veins are invaded, distant skin deposits may occur . In the head and neck region only fifteen cases of cutaneous metastases have been reported .
Cutaneous metastases as a first sign of internal malignancy occur infrequently. More commonly, they are early indicators of metastatic disease . Diagnosis may delay several months  unless the skin lesion grows rapidly or other sites such as the lung or liver are affected by tumour spread. In our case, the cutaneous metastasis went unnoticed for three months and it was the pulmonary symptoms that suggested recurrence of the previous colon adenocarcinoma. Early recognition of tumour relapse from a suspicious skin lesion may lead to initiation of treatment before widespread metastases occur .
In general, skin metastasis is a poor prognostic sign. If the primary tumour is the lung, the cervix or the oesophagus most patients die within three months. In the case of colorectal cancer, however, skin involvement is not a preterminal event . Treatment involves radiotherapy or excision and patients may survive up to a year [3, 10].
Cutaneous metastases in the face from colorectal cancer are very rare and they may go unnoticed for a long period. Usually, they indicate tumour relapse several years after primary resection. Early detection requires high index of suspicion. Therefore, close inspection of new skin lesions in patients with a history of malignancy is imperative, and diagnostic biopsy is essential. Cutaneous metastasis is not a preterminal event and appropriate treatment may prolong patient survival up to a year.
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