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A case of gastrointestinal stromal tumor with spontaneous rupture in the greater omentum
© Yoshimura et al; licensee BioMed Central Ltd. 2008
Received: 27 September 2007
Accepted: 29 July 2008
Published: 29 July 2008
Although GIST generally occurs in the digestive tract, such as the stomach, and small and small intestine primarily, Omental GIST tumours are very rare.
A 63-year-old male patient, who recognized an abdominal tumor 1 year before admission, had a slight expansion of the tumor, reduction of the body and malaise, was consulted to our hospital. Abdominal CT and MRI revealed a cystic lesion of 26 cm in diameter with a clear boundary from immediately below the interseptum to the pelvic cavity, and imaged the septum and cystic wall. We considered that the patient had a cystic tumor in the abdomen, of which the primary lesion was unknown, and scheduled surgery. The patient unfortunately deteriorated with shock and sudden pain in the abdomen. Wediagnosed tumor rapture, and emergency surgery was performed. The tumor, weighing 3,600 g, was mostly cystic, and filled with sanguinous fluid and clot. Histologically, the tumor was composed of spindle cells, and was positive for c-KIT (CD117), slightly positive for alpha-smooth muscle actin (SMA), and S-100 protein positive. Based on these findings, the tumor was diagnosed as GIST primarily occurring in the greater omentum.
We experienced a rare case of GIST which originated from the greater omentum. Recently, the prognosis of GIST has been improved since the treatment with Imatinib.
It is necessary to consider the diagnosis of GIST on encountering a mass in the greater omentum.
Tumours occurring in the greater omentum are rare, and diagnosis of such lesions is difficult. Tumours with the immunohistochemical characteristics of gastrointestinal stromal tumor (GIST), of which the primary lesion is in the greater omentum, have recently been reported. Generally, GIST occurs in the digestive tract, and the incidence of primary GIST lesions in the greater omentum has been reported to be less than 1%. We describe a patient with massive GIST occurring primarily in the greater omentum, which subsequently ruptured spontaneously during the observation period, necessitating emergency surgery.
A 63-year-old male, who recognized an abdominal mass 1 year before this admission, presented with a slight expansion of the tumor, weight loss of 5 kg in 3 months, and malaise. A massive non-tender abdominal tumor was palpated. Haematological examination found anaemia and high levels of CRP and LDH, while the levels of CEA, CA19-9, and AFP were within the normal ranges.
Hematological examination showed no aggravation of anemia.
Generally, GIST occurs primarily in the digestive tract, such as the stomach, and small and large intestine, and the incidence of the primary GIST lesion in the greater omentum is very unusual. Among mesenchymal tumors on the digestive tract wall, KIT-expressing tumors are regarded as GIST, which are considered to be derived from the interstitial cells of Cajal cells.
It has been reported that GIST in the mesentery and greater omentum, structures which lack ICCs, are derived from mesenchymal cells that are less differentiated than ICCs, ICC precursors straying into the abdominal cavity, or KIT-positive cells similar to ICCs immediately below mesothelial cells in the greater omentum. However, the precise aetiology remains to be clarified.
A single patient with spontaneous rupture of GIST in the greater omentum during the observation period has been reported by Shingu et al . They considered that hemorrhage and cystic changes are likely to occur in the greater omentum because it is mainly composed of sparse membrane structures with abundant blood flow, resulting in spontaneous rupture. In our patient, nothing unusual with regard to pathological significance was observed in the ruptured region, and some load on the tumor in addition to its development and changes in the cysts may have caused the rupture. Our patient is the second reported case of spontaneous rupture of GIST in the greater omentum. One should consider GIST as a differenfial diagnosis on encountering a tumour in the greater omentum.
The written consent was obtained from the patient.
- DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF: Two hundred gastrointestinal stromal tumors recurrence pattern and prognostic factor for survival. Ann Surg. 2000, 231: 51-8. 10.1097/00000658-200001000-00008.PubMed CentralView ArticlePubMedGoogle Scholar
- Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hamada M, Kurata A, Takeda M, Tunio Muhammad Ghulam, Matsuzawa Y, Kanakura Y, Hinomura Y, Kitamura Y: Gain-of-function mutation of c-kit gene and molecular target therapy in GISTs. Nippon Shokakibyo Gakkai Zasshi (Jpn J Gastroenterol). 2003, 100: 13-20.Google Scholar
- Miettinen M, Monihan JM, Sarlomo-Rikala M, Kovatich AJ, Carr NJ, Emory TS, Sobin LH: Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol. 1999, 23: 1109-18. 10.1097/00000478-199909000-00015.View ArticlePubMedGoogle Scholar
- Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, Muhammad Tunio G, Matsuzawa Y, Kanakura Y, Shinomura Y, Kitamura Y: Gain-of-functionfmutations of c-kit in human gastrointestinal stromal tumors. science. 1998, 279: 577-80. 10.1126/science.279.5350.577.View ArticlePubMedGoogle Scholar
- Sakurai S, Hishima T, Takazawa Y, Sano T, Nakajima T, Saito K, Morinaga S, Fukayama M: Gastrointestinal stromal tumors and KIT-positive mesenchymal cells in the omentum. Pathol Int. 2001, 51: 524-31. 10.1046/j.1440-1827.2001.01224.x.View ArticlePubMedGoogle Scholar
- Shingu Y, Terasaki M, Okamoto Y, Goto Y, Kurumiya Y, Natsume S: A case of gastrointestinal stromal tumor(GIST) of the omentum. Journal of Japan Surgical association. 2003, 64: 1246-50.View ArticleGoogle Scholar
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