Internal auditory canal metastasis mimicking a vestibular schwannoma at presentation – a case report and review of the literature
© Loo et al; licensee BioMed Central Ltd. 2009
Received: 29 December 2008
Accepted: 31 March 2009
Published: 31 March 2009
Metastasis to the internal auditory canal from breast carcinoma is extremely rare and difficult to diagnose. It radiologically mimics vestibular schwannoma and can occur as a first manifestation of systemic relapse after a long disease-free interval in patients previously treated for early breast cancer. The diagnosis is usually made retrospectively and the optimal management of such metastasis following complete resection remains undefined.
The most common lesion within the internal auditory canal is vestibular schwannoma accounting for approximately 90% of all cases in this area. Metastatic tumours are extremely rare. Here we report just such a case, radiologically mimicking a schwannoma and representing the first clinical recurrence of breast carcinoma after a 13-year interval, in order to raise awareness and highlight the difficulties in pre-operative diagnosis.
The vast majority of lesions within the internal auditory canal are benign tumors, of which vestibular schwannomas account for approximately 90%. Vestibular schwannomas are benign slow growing tumors and tinnitus is the most common initial symptom. Other common symptoms include vertigo and progressive unilateral hearing loss. Facial nerve palsy is considered a late manifestation. Metastases to the normal internal auditory canal are extremely rare. Only very few cases have ever been reported. Two of these were from breast [1, 2]. Marques et al reported on a case of an isolated metastasis in the left cerebellopontine angle and internal auditory canal 16 years after treatment for a breast adenocarcinoma  and Guilemany et al described a patient with a pT2 pN1 M0 invasive ductal carcinoma of the breast who relapsed 5 years later with again an isolated metastasis to the left internal auditory canal and cerebellopontine angle . Both of these cases were very similar to ours with a history of early breast cancer treated radically many years ago with no evidence of tumour recurrence on follow-up and presenting with symptoms of seventh and eighth cranial nerves dysfunction as the first manifestation of systemic relapse after a long disease-free interval.
Even though our MRI findings were consistent with a vestibular schwannoma, the clinical history of rapidly deteriorating sensorineural hearing loss, notably unaccompanied by tinnitus, rapidly succeeded by severe facial nerve palsy might have raised suspicion of an alternative diagnosis. Severe, unremitting pain localized to the mastoid and retromastoid areas has been noted to be a characteristic sign of metastasis to the internal auditory canal .
Pre-operative diagnosis of such metastasis is often difficult as there are no distinctive features on MR imaging that will help to differentiate them from the more common benign lesions. The majority of schwannomas are homogeneous, isointense in signal compared to gray matter on both T1- and T2-weighted images and enhances strongly following gadolinum. Bilateral metastases have been known to mimic neurofibromatosis type 2 .
Thus, the diagnosis of internal auditory canal metastasis is usually made retrospectively following surgical removal of the tumor. Immunohistochemistry is useful in identifying the tissue of origin as such metastasis can be the first sign of an undiagnosed malignancy [4, 5] as well as tumor recurrence after a long disease-free period. Histology can also help to exclude the presence of a collision tumour of schwannoma and metastasis .
The optimal management of such metastases from a breast primary following complete resection is hard to define. In the 2 similar previous cases reported in the literature, where isolated metastasis to both the internal auditory canal and the cerebellopontine angle occurred 16 and 5 years following initial treatment for breast cancer respectively, surgical resection was noted to be complete and both went on to receive post-operative radiotherapy remaining in remission with follow-up of 3 and 18 months respectively [1, 2]. Lobular carcinomas are often slower growing than ductal carcinomas and are more likely to be oestrogen-receptor positive. As our patient was shown to have widespread but asymptomatic bone metastases on further imaging which required the initiation of systemic therapy with anastrozole, local irradiation was not recommended but will be considered in the event of local relapse on subsequent scans.
In conclusion, although internal auditory canal metastases are extremely rare, it should form part of the differential diagnosis when patients present with rapidly progressive and painful deficits of the seventh and eighth cranial nerves. Difficulties will still remain in distinguishing between a metastasis and a benign tumor once MR imaging reveals the presence of a lesion in the internal auditory canal.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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